301482
Schizophrenia,Posit Science,Trial,Positive Result
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50
date
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1
24835
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%20impairment%20in%20ESZ%20individuals%20%28p%20%3D%20.020%29.%20Neither%20ESZ%20intervention%20group%20showed%20significant%20change%20in%20MMN.%20We%20found%20high%20correlations%20in%20all%20MMN%20deviant%20types%20%28rs%20%3D%20.59%5Cu2013.68%2C%20all%20ps%20%3C%20.001%29%20between%20baseline%20and%20post-intervention%20amplitudes%20irrespective%20of%20treatment%20group%2C%20suggesting%20trait-like%20stability%20of%20the%20MMN%20signal.%20Greater%20deficits%20in%20trait-like%20Double-Deviant%20MMN%20predicted%20greater%20cognitive%20improvements%20in%20the%20AT%20group%20%28p%20%3D%20.02%29%2C%20but%20not%20in%20the%20CG%20group.%5Cn%5CnConclusions%5CnIn%20this%20sample%20of%20ESZ%20individuals%2C%20AT%20had%20no%20effect%20on%20auditory%20deviance%20processing%20as%20assessed%20by%20MMN.%20In%20ESZ%20individuals%2C%20baseline%20MMN%20was%20significantly%20reduced%20relative%20to%20HCs%2C%20and%20associated%20with%20global%20cognitive%20impairment.%20MMN%20did%20not%20show%20changes%20after%20AT%20and%20exhibited%20trait-like%20stability.%20Greater%20deficits%20in%20the%20trait%20aspects%20of%20Double-Deviant%20MMN%20predicted%20greater%20gains%20in%20global%20cognition%20in%20response%20to%20AT%2C%20suggesting%20that%20MMN%20may%20identify%20individuals%20who%20stand%20to%20gain%20the%20most%20from%20AT.%22%2C%22date%22%3A%222017%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs40810-017-0024-9%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC5568850%5C%2Fpdf%5C%2Fnihms891857.pdf%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-12-24T00%3A07%3A52Z%22%7D%7D%5D%7D
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